Nutrigenomics

Where genetics meets personalised nutrition

Your genes influence far more than your eye colour. They shape how your body absorbs and utilises nutrients, regulates inflammation, detoxifies, produces energy, and responds to stress - and no two people are the same.

Nutrigenomic testing adds another layer of insight. Rather than applying general nutritional principles, it allows us to identify where your body may have increased needs or reduced efficiency, and tailor recommendations accordingly.

It offers a valuable addition to your nutritional therapy programme.

What does it all mean?

Nutrigenetics examines how your individual genetic variations - known as SNPs (single nucleotide polymorphisms) - may influence the way your body processes and responds to nutrients. These variations are entirely normal and present in everyone, but they can affect how efficiently certain biological pathways function.

Nutrigenomics looks at the other side of this relationship: how nutrition and lifestyle choices can influence the way your genes are expressed.

Together, these two fields help us understand:

where your body may have increased nutritional demands or reduced functional efficiency.
where targeted nutrition and lifestyle strategies may help support or optimise those pathways.

Your DNA is the blueprint you were born with. It doesn't change, but how that blueprint is read is not fixed.

Nutrition and lifestyle play an important role in shaping this, which is what allows a more personalised and clinically relevant approach.

Tests

Methylation Report

This test examines genes involved in five sub-cycles - folate, methionine, neurotransmitter, transsulphuration and urea. Results will provide guidance on how to support or bypass bottlenecks or weaknesses.

Nutrient Core Report

This test analyses how gene variants can affect food tolerance (and intolerance), appetite control and blood sugar balance, vitamin and mineral needs, detoxification ability, and susceptibility to inflammation and infection.

Nervous System Report

This test analyses gene variants that impact serotonin (contentment) and melatonin (sleep), dopamine (motivation), noradrenaline and adrenaline (fight or flight); glutamate (the major excitatory neurotransmitter); GABA (the major inhibitory neurotransmitter) which is critical for relaxation; and endoCannabinoids (AEA/ anandamide) which regulate other neurotransmitters.

Detoxification Report

This test examines genes which impact Phase I reactions in the liver, including the cytochrome P450 oxidases, Phase II conjugation, including the UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs) and the Phase III antiporter gene ABCB1, which affects the transport of medicines and other substances into and out of cells. It also include genes that help to neutralise ROS - due to toxic intermediates (generated in Phase 1).

Thyroid Balance Report

This test analyses the genes involved in the thyroid hormone lifecycle: synthesis - centrally (in the thyroid) and in activation in peripheral tissues, transport and metabolism, processing of cofactors (vitamins D and A) and inhibitors (stress and toxins). It also examines genes that confer susceptibility to inflammation and autoimmunity.

Hormones Report

This test analyses genes involved in the regulation, synthesis, signalling, transport and metabolism of corticosteroids and sex steroids hormones. It looks at how gene variants affect hormone imbalance and details the nutrients and environmental factors that can influence and improve their balance.

Histamine Intolerance

This test analyses the genes and nutrients needed to breakdown and remove histamine, showing where disruptions occur and how to support optimal function. Diamine oxidase (DAO), which primarily breaks down histamine in the gut, can be impaired by various things. Insufficient histamine-n-methyl- transferase (HNMT) in the nervous system and lungs can also lead to histamine overload.

Metabolics Report

Metabolism refers to all cellular chemical reactions and is essential for life. It can be divided into ‘anabolism’ (build-up) and catabolism (break-down). The balance between them, is key to healthy energy metabolism and cellular function. This test transforms our understanding of how genes confer metabolic individuality and underpin energy regulation, longevity and healthspan.

Metals and Minerals Report

This test analyses how gene variants can affect the absorption, distribution and excretion of metals and minerals, impacting their balance and status in the body.

Athlete Report

This test present elements of your unique DNA profile that have been shown to affect athletic performance.

APOE Report

In addition to providing APOE form, this test examines genes involved in methylation, inflammation, toxicity and neuroprotection, to enable individuals to take preventative action by adopting personalised nutrition and lifestyle changes to optimise their future, long term health.

Multi Report

For some clients, a single report does not give the full picture and multiple reports can be combined to provide a more comprehensive view of key pathways.

Multi-report packages can be discussed and tailored based on your individual needs.

Pricing

The cost of the Nutrigenomics service is £499, which includes:

30 min online session to discuss options most useful to you
One Nutrigenomic report of choice (choose from any option listed above).
Full analysis and interpretation (45min online session)
Written report with recommendations

Follow up sessions may be requested to monitor progress at an additional cost.

Additional panels may be added on for £250 per panel and interpretation (including an additional 30 min online session as necessary).

Additional panels ordered within 3 months of the initial DNA test incur no additional costs for further samples.

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